Stabilised beta-carotene · BioFusion technology · IJRPS publication
Carotex®: beta-carotene stabilised with BioFusion technology; 1.70× vs comparator and 2.55× vs control tissue levels in IJRPS study. From Biontera.
Carotex® is a stabilised, high-bioavailability provitamin A source that overcomes beta-carotene's known formulation challenge ; strong hydrophobicity ; through BioFusion technology. Its bioavailability study was published in the peer-reviewed International Journal of Research in Pharmaceutical Sciences (IJRPS).[1]
In a five-arm comparative study, tissue beta-carotene concentration in the Carotex® group measured approximately 1.70× higher than a commercial comparator and 2.55× higher than control ; with retinal levels equivalent across all groups, confirming a safe conversion profile.
Per the WHO, vitamin A deficiency is a systemic condition affecting cells and organs throughout the body, presenting as xerophthalmia, night blindness and xerosis. Beta-carotene is the precursor of vitamin A — which the human body cannot synthesise — and because conversion is need-driven, it avoids the high-dose toxicity risk of preformed vitamin A (retinol).
The practical formulation barrier is beta-carotene's hydrophobic structure and oxidative instability. BioFusion technology stabilises the molecule, extending shelf life and increasing tissue exposure; the stability profile optimised for oil-soluble systems is documented comparatively in the IJRPS publication.
BioFusion stabilisation delivered multi-fold superiority in tissue beta-carotene versus comparator and control while preserving conversion safety. 5-arm controlled study (in-vivo model) · 5 groups · 50 mg/kg · 7 days · 7 days
Every shipment can be delivered with a 12-item technical documentation file on request:
Beta-carotene is a provitamin: the body converts only what it needs. Unlike preformed retinol it carries no high-dose hypervitaminosis A risk; equivalent retinal levels across all groups in the IJRPS study confirm this profile.
It stabilises the hydrophobic beta-carotene molecule, limiting oxidative degradation and increasing tissue exposure ; 1.70× vs comparator and 2.55× vs control in the study.
Oil-based softgels, emulsions and powder premixes; the stability profile is optimised for oil-soluble systems.
Final product dosing is set with your formulation team within applicable regulatory limits and target claims; the technical dossier includes dose scenarios.
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