Proprietary dual polyphenolic complex · green coffee bean + curcumin
Gremin®: dual polyphenolic complex of green coffee bean and curcumin; two clinical publications on muscle recovery and endurance. Distributed by Biontera.
Gremin® is a dual-polyphenolic sports-nutrition ingredient combining green coffee bean extract and curcumin in a single proprietary composition. Its efficacy has been evaluated in two separate clinical publications ; muscle recovery, and endurance/muscle performance.
In the first study (prospective, double-blind, placebo-controlled, n=16), 10 days of Gremin® produced significant reductions in post-eccentric-exercise pain and tenderness together with lower plasma markers of inflammation (CRP) and muscle damage (creatine kinase, lactate dehydrogenase).[1] In the second study (n=60, 14 days, 500 mg/day), endurance measured by the six-minute walk test and VO₂max, isometric muscle strength and MFI fatigue scores improved significantly versus placebo; DEXA showed increased lean body mass.[2]
Eccentric exercise causes muscle damage in the unaccustomed, presenting as delayed soreness (DOMS), strength and range-of-motion loss, swelling and increased passive stiffness. Gremin®'s polyphenol pair targets this picture on two fronts: the chlorogenic-acid-rich green coffee fraction addresses oxidative load, while the curcumin fraction modulates the inflammatory response.
The combined profile of the two studies — reductions in recovery markers (CK, LDH, CRP) alongside gains in endurance metrics (VO₂max, 6MWT) — gives formulators flexibility across both the pre-workout and recovery categories.
Significant reductions versus placebo in inflammation and muscle-damage markers after eccentric exercise; improved pain scores. Prospective, double-blind, placebo-controlled, randomised · n = 16 healthy volunteers · Daily · 10 days
Significant improvement versus placebo in endurance, muscle strength and fatigue (MFI); increased lean body mass on DEXA. Randomised, placebo-controlled · n = 60 healthy adults · 500 mg/day · 14 days
Every shipment can be delivered with a 12-item technical documentation file on request:
Chlorogenic-acid-rich green coffee bean extract and curcumin ; in proprietary ratios within one composition. The two polyphenol families target oxidative stress and the inflammatory response through complementary mechanisms.
Two separate publications: (1) muscle recovery ; CK, LDH, CRP markers and pain scores; (2) endurance and muscle performance ; VO₂max, six-minute walk test, isometric strength, MFI fatigue and DEXA body composition.
The second clinical study used a single 500 mg daily dose, which fits in one capsule.
The composition is standardised on polyphenol fractions; caffeine content is reported on the lot CoA, and stimulant-free positioning should be assessed with our technical team.
