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Metaberine®

Bio-optimised berberine · BioSOLVE® technology

Metaberine®: bio-optimised berberine on the BioSOLVE® platform. Significant glucose improvements in a double-blind crossover RCT (n=36, 200 mg); IJCT 2026.

Metaberine®

Berberine is among the most-researched metabolic actives of the past decade, with a broad literature base on glucose balance and lipid profile. The molecule's practical limit is equally clear: it is water-insoluble, poorly absorbed, and subject to P-glycoprotein efflux. Metaberine® was designed to overcome that limit with the BioSOLVE® platform.

The BioSOLVE® matrix renders berberine water-dispersible, delivering approximately 4× bioavailability versus standard market berberine HCl.[1] The same plasma exposure can therefore be achieved at a lower label dose ; meaning smaller dosage units and a wider gastrointestinal tolerance window.

Formulations targeting the glucose-balance research area
Lipid-profile support complexes
Weight-management and metabolic-syndrome support lines
Combinations with chromium, alpha-lipoic acid, cinnamon extract
Low-dose-unit capsule/tablet design
n=36
Randomised, double-blind, crossover RCT
200mg
Daily clinical dose · 14 days
Clinical and Technical Evidence

Berberine's gastrointestinal side-effect profile is dose-dependent; the high doses required to reach effective plasma levels with standard forms (1000–1500 mg/day) strain formulation design. A bioavailability gain changes that equation: equivalent exposure becomes possible at lower doses, reducing tablet size and the need for divided dosing.

The absorption architecture validated for the BioSOLVE® platform in its curcumin application through a human cross-over study (see BioSOLVE Curcumin®) is applied to berberine on the same formulation principle. It is positioned as a reference active for formulations targeting the glucose-balance, lipid-profile and weight-management research areas.

Clinical · RCTInt J Clin Trials · 2026

Metabolic-health study in healthy adults

Significant improvement versus placebo in fasting and postprandial glucose response measured by OGTT; total cholesterol and LDL-C decreased while HDL-C increased. Full participant retention with no supplement-related adverse events. Randomised, double-blind, placebo-controlled crossover (7-day washout) · n = 36 (fasting glucose 100–125 mg/dl) · 200 mg/day · 14 days × 2 periods

−9.08 mg/dl (placebo −1.36; p<0.0001)
Fasting glucose
−13.5% / −12.7% (p<0.0001)
Glucose AUC / Cmax
+29% fasting · +22% postprandial (p<0.0001)
Plasma GLP-1
BioavailabilityZeus Hygia technical file

Absorption comparison vs standard berberine

The BioSOLVE® matrix delivers roughly 4× plasma exposure versus standard berberine HCl; the 200 mg clinical dose builds on this absorption advantage. Comparative pharmacokinetic assessment · Equivalent berberine basis

≈4×
Relative bioavailability
Water-dispersible powder
Format
5–7-fold lower dose than conventional preparations
Dose strategy
Identity and Technical Dossier

Every shipment can be delivered with a 12-item technical documentation file on request:

Lot-based Certificate of Analysis (CoA)
GMP certificate
Product specification
Analytical methods
MSDS safety data sheet
TDS technical data sheet
Stability and shelf-life data
Manufacturing flow chart
Certificate of origin
Allergen and GMO-free statement
BSE/TSE statement
Halal and Kosher certificates (on request)
Frequently Asked Questions
How does Metaberine® differ from standard berberine HCl? +

Standard berberine is water-insoluble and its absorption is limited by P-glycoprotein efflux. Metaberine® is made water-dispersible on the BioSOLVE® platform and delivers approximately 4× bioavailability.

What does the lower dose enable? +

Equivalent plasma exposure at a lower label dose: smaller tablets/capsules, single-unit dosing, and a wider gastrointestinal tolerance window.

Which combinations does it work with? +

Compatible with metabolic-support components such as chromium picolinate, alpha-lipoic acid, cinnamon extract and inositol; combination strategy can be planned with our technical team.

What is in the technical file? +

Comparative bioavailability data, specification, stability and CoA template; full disclosure after an NDA.

References
  1. [1]Jeyakodi S, Krishnakumar A, Naik DN, Nisa MMH, Thomas JV. Metaberine (bio-optimised berberine 200 mg/day) improves metabolic health markers in healthy adults: a randomized, double-blind and placebo-controlled crossover trial.International Journal of Clinical Trials, 2026;13(3):270-282 · doi:10.18203/2349-3259.ijct20262501
  2. [2]Metaberine®: bio-optimized berberine on the BioSOLVE® platform; comparative bioavailability data vs standard berberine.Zeus Hygia Lifesciences technical file
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First Step

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